In-vitro Antispasmodic Activity Analysis of Methanolic Leaves Extract of Lantana camara Linn. on Excised Rat Ileum

Abstract

This study was aimed to provide the pharmacological basis for medicinal use of Lantana camara Linn. as an antispasmodic agent using in-vitro pharmacological assay. Lantana camara Linn. (Verbenaceae), is a widely growing shrub which found to be toxic to some animal species, has been used in the traditional medicine for treating many ailments. The purpose of the present study was to evaluate the antispasmodic effects of Lantana camara leaf constituents on rat ileum. Antispasmodic activity was assessed by the interpolation method on isolated rat ileum. Effects of acetylcholine, methanolic extract of Lantana camara leaves and acetylcholine along with methanolic leaves extract were studied on isolated rat ileum; which later compared with atropine as standard anti-spasmodic agent. The present study results revealed that methanolic leaves extract of Lantana camara Linn. Showed promising antispasmodic action on excised rat ileum