article

Chemical composition, antimicrobial, and cytotoxic assessment of Mitracarpus scaber Zucc. (Rubiaceae) essential oil from southwestern Nigeria

American Journal of Essential Oils and Natural Products · 2013 · Vol. 1(1) · pp. 04–06

Moses S. Owolabi✉Oladipupo A. LawalNoura S. DosokyPrabodh SatyalWilliam N. Setzer

Abstract

The leaf essential oil composition of Mitracarpus scaber was determined by GC-MS. The oil was dominated by pentadecanal (38.5%), methyl (7Z, 10Z, 13Z)-hexadecatrienoate (11.8%), 2, 3-dimethylnaphthoquinone (6.0%), and α-pinene (5.4%). The oil was screened for antimicrobial activity using the broth dilution technique and screened for in-vitro cytotoxic activity against human MCF-7 breast tumor cells. M. scaber leaf oil showed only marginal antibacterial activity against Bacillus cereus (MIC = 625 μg/mL), marginal antifungal activity against Aspergillus niger (MIC = 313 μg/mL), and marginal cytotoxic activity on MCF-7 cells (58.7±7.6% kill at 100 μg/mL).

Essential Oils and Antimicrobial Activity Ethnobotanical and Medicinal Plants Studies Phytochemistry and Biological ActivitiesAntimicrobialBacillus cereusAspergillus nigerRubiaceaeEssential oilTraditional medicineFood scienceCytotoxic T cellChemistryBiology

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