Analysis of pattern of change of VAS and WOMAC between autologous bone marrow derived mesenchymal stem cells enhanced with platelet rich plasma versus platelet rich plasma in osteoarthritis knee

Abstract

Introduction: Osteoarthritis (OA) is a chronic degenerative disorder that is characterized by a loss of articular cartilage, in the synovial joints which is characterized by sclerosis subchondral bone thickening, marginal osteochondral outgrowths (osteophytes). Several risk factors have been identified, such as obesity, occupation, higher age, biomechanics and increased dynamic loading of the joint and joint injury, and invoves the weight bearing joints like hip and knee joint Methodology: The sample size studied was 32 patients of which 16 patients in each group.The patients were selected after going through the inclusion and exclusion criteria. The patients were examined clinically regarding VAS score KOOS score and WOMAC score recorded each patient was investigated by routine blood tests investigation X ray, MRI Results: The group 1 had baseline pain score of mean 9.38 with (SD±2.187) and in group 2 had baseline pain score of mean 9.13 (SD±1.586). Both groups were comparable and were statistically significant with p value of 0.571. At final follow up, WOMAC score of group 1 had mean 1.25 (SD±0.557) and group 2 had mean of 1.00 (SD±0.00), It was not significant (p= 0.74). Conclusion: A trend towards gradual and progressive decline of the VAS is noted in the patients over the period of three follow ups from the baseline score