Antinociceptive, anti-inflammatory and central nervous system depressant activities of crude methanol extract and its dichloromethane, chloroform and aqueous fractions of Scurrula parasitica (Linn.) leaves

Abstract

Scurrula parasitica (Linn.) has been used as traditional medicine against various diseases. Aim of the study was to evaluate analgesic, anti-inflammatory and CNS-depressant effects of methanol (MSPL), dichloromethane (DSPL), chloroform (CSPL) and aqueous (ASPL) extracts of S. parasitica leaves. Acetic acid-induced writhing and heat-induced tail immersion tests were used to evaluate analgesic effect while carrageenan-induced paw edema model was applied to find out anti-inflammatory potential at100 and 200 mg/kg, b.w dose. The CNS-depressant effect of the extracts were evaluated by using open field and hole cross tests. All the extracts significantly (Pb