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Allergen immunotherapy for IgE‐mediated food allergy: a systematic review and meta‐analysis

Allergy · 2017 · Vol. 72(8) · pp. 1133–1147

Ulugbek Nurmatov(Cardiff University)Sangeeta Dhami✉(Evidence Based Research (United States))Stefania Arasi(University of Messina)Giovanni Battista Pajno(University of Messina)Montserrat Fernández‐Rivas(Hospital Clínico San Carlos)Antonella MuraroGraham Roberts(NIHR Southampton Respiratory Biomedical Research Unit)Cezmi A. Akdiş(Institute for Asthma and Allergy)Montserrat Álvaro‐Lozano(Hospital Sant Joan de Déu Barcelona)Kirsten Beyer(Charité - Universitätsmedizin Berlin)Carsten Bindslev‐Jensen(Odense University Hospital)Wesley Burks(University of North Carolina at Chapel Hill)George Du Toit(King's College London)Motohiro Ebisawa(National Sagamihara Hospital)Philippe Eigenmann(University of Geneva)Edward F. Knol(University Medical Center Utrecht)Mika J. Mäkelä(Helsinki University Hospital)Kari C. Nadeau(Stanford University)Liam O’Mahony(University of Zurich)Nikolaos G. Papadopoulos(National and Kapodistrian University of Athens)Lars K. Poulsen(Gentofte Hospital)Cansın Saçkesen(Koç University)Hugh A. Sampson(World Allergy Organization)Alexandra F. Santos(St Thomas' Hospital)Ronald van Ree(Amsterdam UMC Location University of Amsterdam)Frans TimmermansAziz Sheikh(Farr Institute)

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Abstract

AIT may be effective in raising the threshold of reactivity to a range of foods in children with IgE-mediated food allergy whilst receiving (i.e. desensitization) and post-discontinuation of AIT. It is, however, associated with a modest increased risk in serious systemic adverse reactions and a substantial increase in minor local adverse reactions. More data are needed in relation to adults, long term effects, the impact on QoL and the cost-effectiveness of AIT.

Food Allergy and Anaphylaxis Research Allergic Rhinitis and Sensitization Asthma and respiratory diseasesMedicineAllergyImmunoglobulin EMeta-analysisFood allergyAllergenImmunotherapyOral immunotherapyImmunologyDesensitization (medicine)

MeSH terms

AllergensAnimalsDesensitization, ImmunologicFoodFood HypersensitivityHumansImmunoglobulin EQuality of LifeOdds RatioTreatment OutcomeSublingual Immunotherapy