review Open AccessTop 1% cited
Molecular chess? Hallmarks of anti-cancer drug resistance
BMC Cancer · 2017 · Vol. 17(1) · pp. 10–10
Ian A. Cree✉(University Hospitals Coventry and Warwickshire NHS Trust)Peter Charlton(Imperial Innovations (United Kingdom))
Abstract
The oncologist is now required to be at least one step ahead of the cancer, a process that can be likened to 'molecular chess'. Thus, as well as an increasing role for predictive biomarkers to clinically stratify patients, it is becoming clear that personalised strategies are required to obtain best results.
Lung Cancer Treatments and MutationsHER2/EGFR in Cancer ResearchColorectal Cancer Treatments and StudiesSurgical oncologyDrug resistanceMedicineCancer drugsDrugCancerResistance (ecology)BioinformaticsOncologyPharmacology
MeSH terms
HumansMedical OncologyNeoplasmsDrug Resistance, NeoplasmPrecision Medicine
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327
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22.08
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102
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References
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Cell Death and Differentiation · 2008 · 3,307 citations
Molecular mechanisms of drug resistance
The Journal of Pathology · 2005 · 1,646 citations
p53 Family and Cellular Stress Responses in Cancer
Frontiers in Oncology · 2014 · 289 citations
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
New England Journal of Medicine · 2004 · 11,455 citations
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Science · 2015 · 7,864 citations
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
British Journal of Cancer · 1972 · 15,557 citations
Cancer heterogeneity: implications for targeted therapeutics
British Journal of Cancer · 2013 · 990 citations
Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation
Clinical Cancer Research · 2005 · 828 citations
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