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Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures

Genome biology · 2016 · Vol. 17(1) · pp. 231–231

Yasin Şenbabaoğlu✉(Swim Across America)Ron S. Gejman(Cornell University)Andrew Winer(Memorial Sloan Kettering Cancer Center)Ming Liu(Memorial Sloan Kettering Cancer Center)Eliezer M. Van Allen(Dana-Farber Cancer Institute)Guillermo de Velasco(Dana-Farber Cancer Institute)Diana Miao(Dana-Farber Cancer Institute)Irina Ostrovnaya(Memorial Sloan Kettering Cancer Center)Esther Drill(Memorial Sloan Kettering Cancer Center)Augustin Luna(Memorial Sloan Kettering Cancer Center)Nils Weinhold(Memorial Sloan Kettering Cancer Center)William Lee(Memorial Sloan Kettering Cancer Center)Brandon J. Manley(Memorial Sloan Kettering Cancer Center)Danny N. Khalil(Memorial Sloan Kettering Cancer Center)Samuel D. Kaffenberger(Memorial Sloan Kettering Cancer Center)Ying‐Bei Chen(Memorial Sloan Kettering Cancer Center)Ludmila Danilova(Vavilov Institute of General Genetics)Martin H. Voss(Memorial Sloan Kettering Cancer Center)Jonathan Coleman(Memorial Sloan Kettering Cancer Center)Paul Russo(Memorial Sloan Kettering Cancer Center)Victor E. Reuter(Memorial Sloan Kettering Cancer Center)Timothy A. Chan(Memorial Sloan Kettering Cancer Center)Emily H. Cheng(Memorial Sloan Kettering Cancer Center)David A. Scheinberg(Memorial Sloan Kettering Cancer Center)Ming O. Li(Memorial Sloan Kettering Cancer Center)Toni K. Choueiri(Dana-Farber Cancer Institute)James J. Hsieh(Memorial Sloan Kettering Cancer Center)Chris Sander(Memorial Sloan Kettering Cancer Center)A. Ari Hakimi(Memorial Sloan Kettering Cancer Center)

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Abstract

Our analysis sheds light on the immune infiltration patterns of 19 human cancers and unravels mRNA signatures with prognostic utility and immunotherapeutic biomarker potential in ccRCC.

Cancer Immunotherapy and Biomarkers Ferroptosis and cancer prognosis Immune cells in cancerImmune systemBiologyClear cell renal cell carcinomaCD8ImmunotherapyTranscriptomeInfiltration (HVAC)AntigenCancer researchCell

MeSH terms

Carcinoma, Renal CellComputer SimulationHumansImmunotherapyNeoplasm ProteinsPrognosisRNA, MessengerGene Expression Regulation, NeoplasticLymphocytes, Tumor-InfiltratingCD8-Positive T-LymphocytesProteomicsTumor MicroenvironmentNucleotide Motifs