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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

Cell Metabolism · 2016 · Vol. 24(5) · pp. 657–671

Almut Brand(University Hospital Regensburg)Katrin Singer(University Hospital Regensburg)Gudrun E. Koehl(University Hospital Regensburg)Marlene Kolitzus(University Hospital Regensburg)Gabriele Schoenhammer(University Hospital Regensburg)Annette Thiel(University Hospital Regensburg)Carina Matos(University Hospital Regensburg)Christina Bruß(University Hospital Regensburg)Sebastian Klobuch(University Hospital Regensburg)Katrin Peter(University of Regensburg)Michael Kastenberger(University Hospital Regensburg)Christian Bogdan(Universitätsklinikum Erlangen)Ulrike Schleicher(Universitätsklinikum Erlangen)Andréas Mackensen(Universitätsklinikum Erlangen)Evelyn Ullrich(Universitätsklinikum Erlangen)Stefan Fichtner‐Feigl(University of Regensburg)Rebecca Kesselring(University Hospital Regensburg)Matthias Mack(University Hospital Regensburg)Uwe Ritter(University of Regensburg)Maximilian Schmid(University Hospital Regensburg)Christian U. Blank(The Netherlands Cancer Institute)Katja Dettmer(University of Regensburg)Peter J. Oefner(University of Regensburg)Petra Hoffmann(University of Regensburg)Stefan Walenta(Johannes Gutenberg University Mainz)Edward K. Geissler(University Hospital Regensburg)Jacques Pouysségur(Scientific Centre of Monaco)Andreas Villunger(Innsbruck Medical University)André Steven(Martin Luther University Halle-Wittenberg)Barbara Seliger(Martin Luther University Halle-Wittenberg)Stephan Schreml(University Hospital Regensburg)Sebastian Haferkamp(University Hospital Regensburg)Elisabeth Kohl(University Hospital Regensburg)Sigrid Karrer(University Hospital Regensburg)Mark Berneburg(University Hospital Regensburg)Wolfgang Herr(University Hospital Regensburg)Wolfgang Mueller‐Klieser(University Medical Center of the Johannes Gutenberg University Mainz)Kathrin Renner(University of Regensburg)Marina Kreutz✉(University Hospital Regensburg)

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Immune Cell Function and Interaction Cancer, Hypoxia, and Metabolism Cancer Research and TreatmentsImmunosurveillanceLactic acidGlycolysisCancer researchCell biologyChemistryBiologyTumor cellsBiochemistryMetabolism

MeSH terms

Lactate Dehydrogenase 5AnimalsCell CountCell SurvivalGlycolysisHumansImmunologic SurveillanceInterferon-gammaIsoenzymesKiller Cells, NaturalL-Lactate DehydrogenaseMaleMelanomaMice, Inbred C57BLPhenotype

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The Science and Translation of Lactate Shuttle Theory