review Open AccessTop 10% cited
The kynurenine pathway and the brain: Challenges, controversies and promises
Neuropharmacology · 2016 · Vol. 112(Pt B) · pp. 237–247
Robert Schwarcz✉(University of Maryland, Baltimore)Trevor W. Stone(University of Glasgow)
Tryptophan and brain disordersStress Responses and CortisolBipolar Disorder and TreatmentKynurenine pathwayNeurosciencePsychologyCognitive scienceKynurenineBiologyGenetics
MeSH terms
AnimalsBrainHumansKynurenineNervous System DiseasesMetabolic Networks and Pathways
Funding
- National Institutes of Health
Citations
433
FWCI
7.79
field-weighted impact
References
191
Percentile
99%
vs. same field & year
Citations per year
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References
Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism
Journal of Neurochemistry · 1991 · 759 citations
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
Behavioural Brain Research · 2014 · 1,932 citations
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation
Neuroscience Letters · 1981 · 464 citations
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
Brain Research · 1982 · 848 citations
Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid
Neuroscience Letters · 1984 · 434 citations
Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS
European Journal of Pharmacology · 1981 · 751 citations
Dynamic mapping of human cortical development during childhood through early adulthood
Proceedings of the National Academy of Sciences · 2004 · 5,541 citations
Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases
Neuropharmacology · 2016 · 376 citations
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