article Open AccessTop 1% cited
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation
Cell Metabolism · 2016 · Vol. 24(1) · pp. 158–166
Vicky Lampropoulou(Washington University in St. Louis)Alexey Sergushichev(ITMO University)Monika Bambousková(Washington University in St. Louis)Sharmila Nair(Washington University in St. Louis)Emma E. Vincent(McGill University Health Centre)Ekaterina Loginicheva(Washington University in St. Louis)Luisa Cervantes‐Barragán(Washington University in St. Louis)Xiucui Ma(Washington University in St. Louis)Stanley Ching‐Cheng Huang(Washington University in St. Louis)Takla Griss(McGill University Health Centre)Carla J. Weinheimer(Washington University in St. Louis)Shabaana A. Khader(Washington University in St. Louis)Gwendalyn J. Randolph(Washington University in St. Louis)Edward J. Pearce(University of Freiburg)Russell G. Jones(McGill University Health Centre)Abhinav Diwan(Washington University in St. Louis)Michael Diamond(Washington University in St. Louis)Maxim N. Artyomov✉(Washington University in St. Louis)
Immune cells in cancerAutophagy in Disease and TherapySphingolipid Metabolism and SignalingEffectorMacrophageInflammationCitric acid cycleMitochondrionCell biologyBiologyCytokineRegulatorMetabolic pathway
MeSH terms
AnimalsFemaleInflammationLipopolysaccharidesMacrophage ActivationMacrophagesMice, Inbred C57BLMitochondriaSuccinate DehydrogenaseSuccinatesReperfusion InjuryReactive Oxygen SpeciesCell RespirationSuccinic Acid
Funding
- U.S. Department of Veterans Affairs
- McGill University
- Deutsches Krebsforschungszentrum
- Regeneron Pharmaceuticals
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- University of California, Davis
- Canadian Institutes of Health Research
Citations
1,433
FWCI
37.93
field-weighted impact
References
22
Percentile
100%
vs. same field & year
Citations per year
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References
Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization
Immunity · 2015 · 1,928 citations
Context-Specific Metabolic Networks Are Consistent with Experiments
PLoS Computational Biology · 2008 · 623 citations
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