article Open AccessTop 10% cited
A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors (Short Communication)
Biochemical Journal · 1974 · Vol. 137(1) · pp. 143–144
Athel Cornish‐Bowden✉(University of Birmingham)
Abstract
A new method is described for plotting kinetic results for inhibited enzyme-catalysed reactions. It provides a simple way of determining the inhibition constant, K'(i), of an uncompetitive, mixed or non-competitive inhibitor.
Computational Drug Discovery MethodsSimple (philosophy)Uncompetitive inhibitorChemistryMathematicsBiological systemNon-competitive inhibitionApplied mathematicsBiochemistryBiologyEnzyme
MeSH terms
Binding SitesBinding, CompetitiveEnzyme InhibitorsEvaluation Studies as TopicKineticsMathematicsMethodsModels, ChemicalProtein Binding
Citations
932
FWCI
14.09
field-weighted impact
References
5
Percentile
99%
vs. same field & year
Citations per year
References
The determination of enzyme inhibitor constants
Biochemical Journal · 1953 · 4,075 citations
Related articles
Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
Biochemical Pharmacology · 1973 · 12,855 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.