article Open AccessTop 1% cited

Characterization of Lethal Zika Virus Infection in AG129 Mice

PLoS neglected tropical diseases · 2016 · Vol. 10(4) · pp. e0004682–e0004682

Matthew T. Aliota(University of Wisconsin–Madison)Elizabeth A. Caine(University of Wisconsin–Madison)Emma C. Walker(University of Wisconsin–Madison)Katrina E. Larkin(University of Wisconsin–Madison)Erwin Camacho(University of Wisconsin–Madison)Jorge E. Osorio✉(University of Wisconsin–Madison)

View via DOI Full-text PDF

Abstract

Foot pad injection of AG129 mice with ZIKV represents a biologically relevant model for studying ZIKV infection and disease development following wild-type virus inoculation without the requirement for adaptation of the virus or intracerebral delivery of the virus. This newly developed Zika disease model can be exploited to identify determinants of ZIKV virulence and reveal molecular mechanisms that control the virus-host interaction, providing a framework for rational design of acute phase therapeutics and for vaccine efficacy testing.

Mosquito-borne diseases and control Viral Infections and Vectors Malaria Research and ControlZika virusVirologyMicrocephalyBiologyOutbreakVirusFlavivirusVirulenceImmunologyMedicine

MeSH terms

Zika Virus InfectionInterferon gamma ReceptorAnimalsBrainDeathDisease Models, AnimalMusclesViremiaReceptors, InterferonMice, KnockoutMiceReceptor, Interferon alpha-beta