articleTop 1% cited
Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions
Organic & Biomolecular Chemistry · 2004 · Vol. 3(1) · pp. 84–84
Alexander J. A. Cobb(University of Cambridge)David M. Shaw(University of Cambridge)Deborah A. Longbottom(University of Cambridge)Johan Gold(University of Cambridge)Steven V. Ley✉(University of Cambridge)
Abstract
Tetrazole and acylsulfonamide organocatalysts derived from proline have been synthesised and applied to the asymmetric Mannich, nitro-Michael and aldol reactions to give results that are superior to the proline-catalysed counterpart.
Synthesis of Tetrazole DerivativesAsymmetric Synthesis and CatalysisChemical Synthesis and ReactionsChemistryAldol reactionOrganocatalysisNitroMichael reactionProlineCatalysisMannich reactionOrganic chemistryCombinatorial chemistry
MeSH terms
CatalysisKetonesModels, MolecularNitro CompoundsProlineStereoisomerismSulfonamidesTetrazolesMolecular StructureCrystallography, X-Ray
Citations
487
FWCI
33.06
field-weighted impact
References
41
Percentile
100%
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References
Proline-Catalyzed Direct Asymmetric Aldol Reactions
Journal of the American Chemical Society · 2000 · 2,809 citations
Proline-catalyzed asymmetric reactions
Tetrahedron · 2002 · 1,146 citations
Enamine-Based Organocatalysis with Proline and Diamines: The Development of Direct Catalytic Asymmetric Aldol, Mannich, Michael, and Diels−Alder Reactions
Accounts of Chemical Research · 2004 · 1,356 citations
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Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions
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