article Open AccessTop 1% cited
Fungal microbiota dysbiosis in IBD
Gut · 2016 · Vol. 66(6) · pp. 1039–1048
Harry Sokol✉(AgroParisTech)Valentin Leducq(Institut thématique Immunologie, inflammation, infectiologie et microbiologie)Hugues Aschard(Harvard University)Hang‐Phuong Pham(Sorbonne Université)Sarah Jégou(Sorbonne Université)Cécilia Landman(Sorbonne Université)David Cohen(Université Paris-Saclay)Giuseppina Liguori(Universidad de Alcalá)Anne Bourrier(Sorbonne Université)Isabelle Nion–Larmurier(Sorbonne Université)Jacques Cosnes(Assistance Publique – Hôpitaux de Paris)Philippe Seksik(Hôpital Saint-Antoine)Philippe Langella(Institut thématique Immunologie, inflammation, infectiologie et microbiologie)David Skurnik(Harvard University)Mathias L. Richard(Sorbonne Université)Laurent Beaugerie(Hôpital Saint-Antoine)
Abstract
Besides bacterial dysbiosis, our study identifies a distinct fungal microbiota dysbiosis in IBD characterised by alterations in biodiversity and composition. Moreover, we unravel here disease-specific inter-kingdom network alterations in IBD, suggesting that, beyond bacteria, fungi might also play a role in IBD pathogenesis.
Gut microbiota and healthProbiotics and Fermented FoodsClostridium difficile and Clostridium perfringens researchDysbiosisBiologyMicrobiologyGut floraPathogenesisInflammatory bowel diseaseImmunologyDiseaseMicrobiomeSaccharomyces boulardii
MeSH terms
Gastrointestinal MicrobiomeAscomycotaBacteriaBasidiomycotaCandida albicansColitis, UlcerativeCrohn DiseaseFecesHumansRNA, Ribosomal, 16SSaccharomyces cerevisiaeCase-Control StudiesPolymorphism, Single NucleotideDysbiosis
Funding
- Institut National de la Santé et de la Recherche Médicale
- Assistance publique-Hôpitaux de Paris
- Association Francois Aupetit
Citations
1,302
FWCI
48.39
field-weighted impact
References
47
Percentile
100%
vs. same field & year
Citations per year
Cited by
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References
Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
Gut · 2012 · 904 citations
Systematic review and meta-analysis of<i>Saccharomyces boulardii</i>in adult patients
World Journal of Gastroenterology · 2010 · 506 citations
<i>Faecalibacterium prausnitzii</i> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Proceedings of the National Academy of Sciences · 2008 · 4,255 citations
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Genome biology · 2012 · 2,736 citations
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