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Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

Gut · 2012 · Vol. 62(4) · pp. 531–539

Henri Duboc(Assistance Publique – Hôpitaux de Paris)Sylvie Rajca(Sorbonne Université)Dominique Rainteau(Hôpital Saint-Antoine)David BenarousMarie-Anne Maubert(Assistance Publique – Hôpitaux de Paris)Elodie Quervain(Laboratoire des Biomolécules)Ginette Thomas(Sorbonne Université)Véronique Barbu(Sorbonne Université)Lydie Humbert(Hôpital Saint-Antoine)Guillaume Despras(Laboratoire des Biomolécules)Chantal Bridonneau(Microbiologie de l’alimentation au service de la santé)Fabien Dumetz(Microbiologie de l’alimentation au service de la santé)Jean-Pierre Grill(Laboratoire des Biomolécules)J. Masliah(Laboratoire des Biomolécules)Laurent Beaugerie(Laboratoire des Biomolécules)Jacques Cosnes(Sorbonne Université)Olivier Chazouillères(Assistance Publique – Hôpitaux de Paris)Raoul Poupon(Hôpital Saint-Antoine)Claude Wolf(Inserm)Jean‐Maurice Mallet(Laboratoire des Biomolécules)Philippe Langella(Microbiologie de l’alimentation au service de la santé)Germain Trugnan(Inserm)Harry Sokol(Hôpital Saint-Antoine)Philippe Seksik✉(Laboratoire des Biomolécules)

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Abstract

Impaired microbiota enzymatic activity observed in IBD-associated dysbiosis leads to modifications in the luminal BA pool composition. Altered BA transformation in the gut lumen can erase the anti-inflammatory effects of some BA species on gut epithelial cells and could participate in the chronic inflammation loop of IBD.

Drug Transport and Resistance Mechanisms Gut microbiota and health Inflammatory Bowel DiseaseDysbiosisGut floraInflammationDeoxycholic acidFecesInternal medicineInflammatory bowel diseaseImmunologyChemistryMicrobiology

MeSH terms

AnimalsBile Acids and SaltsChromatography, High Pressure LiquidColonic NeoplasmsEnzyme-Linked Immunosorbent AssayFecesHumansInflammatory Bowel DiseasesChi-Square DistributionStatistics, NonparametricArea Under CurveCell Line, TumorMiceTandem Mass SpectrometryMetagenome

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904

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13.15

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Gut microbiota-derived metabolites as central regulators in metabolic disorders