articleTop 1% cited
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Nature Neuroscience · 2015 · Vol. 18(11) · pp. 1584–1593
Hirohide Asai✉(Boston University)Seiko Ikezu(Boston University)Satoshi Tsunoda(Boston University)Maria Medalla(Boston University)Jennifer I. Luebke(Boston University)Tarik F. Haydar(Boston University)Benjamin Wolozin(Boston University)Oleg Butovsky(Boston University)Sebastian Kügler(Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103)Tsuneya Ikezu(Boston University)
Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanismsMicrogliaTauopathyEntorhinal cortexDentate gyrusHippocampal formationExosomeNeuroscienceHippocampusTau proteinBiology
MeSH terms
Alzheimer DiseaseAnimalsDisease Models, AnimalHippocampusMaleMice, TransgenicNeuronstau ProteinsMicrogliaEntorhinal CortexExosomes
Citations
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References
A new and rapid colorimetric determination of acetylcholinesterase activity
Biochemical Pharmacology · 1961 · 26,665 citations
Monoclonal antibody PHF‐1 recognizes tau protein phosphorylated at serine residues 396 and 404
Journal of Neuroscience Research · 1994 · 483 citations
Membrane vesicles as conveyors of immune responses
Nature reviews. Immunology · 2009 · 3,812 citations
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau
Journal of Neuroscience Research · 1997 · 560 citations
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Neuron · 2012 · 3,978 citations
Neuropathological stageing of Alzheimer-related changes
Acta Neuropathologica · 1991 · 16,076 citations
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Neuron · 2007 · 2,239 citations
Extracellular vesicles: biology and emerging therapeutic opportunities
Nature Reviews Drug Discovery · 2013 · 3,388 citations
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