article Open AccessTop 1% cited
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Neuron · 2007 · Vol. 53(3) · pp. 337–351
Yasumasa Yoshiyama(University of Pennsylvania)Makoto Higuchi(University of Pennsylvania)Bin Zhang(Institute on Aging)Shu-Ming Huang(RIKEN Center for Brain Science)Nobuhisa Iwata(RIKEN Center for Brain Science)Takaomi C. Saido(RIKEN Center for Brain Science)Jun MaedaTetsuya SuharaJohn Q. Trojanowski(University of Pennsylvania)Virginia M.‐Y. Lee✉(Institute on Aging)
Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchTauopathyHippocampal formationNeuroscienceSynapseNeuroinflammationTau proteinEntorhinal cortexAtrophyHippocampusNeurodegeneration
MeSH terms
AgingAmygdalaAnimalsAtrophyBrainGliosisHumansImmunohistochemistryImmunosuppressive AgentsMacrophage ActivationMicroscopy, ElectronMicrotubulesNerve DegenerationPhosphorylationSolubility
Funding
- University of Pennsylvania
- Astellas Foundation for Research on Metabolic Disorders
Citations
2,239
FWCI
27.21
field-weighted impact
References
64
Percentile
100%
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Citations per year
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References
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Annals of Neurology · 1991 · 4,370 citations
The distribution of tau in the mammalian central nervous system.
The Journal of Cell Biology · 1985 · 1,596 citations
A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
Journal of the Neurological Sciences · 1987 · 614 citations
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Neurology · 1992 · 2,673 citations
Neurodegenerative Tauopathies
Annual Review of Neuroscience · 2001 · 2,357 citations
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