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The Cytotoxic Activity of Annona muricata Leaf Oil from Badagary, Nigeria

Abstract

The leaf essential oil of Annona muricata, collected from Badagary, Nigeria, was obtained by hydrodistillation and analyzed by gas chromatography – mass spectrometry. The leaf oil was dominated by (E)-caryophyllene (38.9%) and eugenol (30.2%), with lesser amounts of α-humulene (4.3%), δ-cadinene (6.0%), and caryophyllene oxide (5.0%). A. muricata leaf oil showed notable invitro cytotoxic activity on MCF-7 cells (99.2% kill at 100 μg/mL), which can be attributed to the major components.

Traditional and Medicinal Uses of AnnonaceaeEssential Oils and Antimicrobial ActivityNatural product bioactivities and synthesisAnnona muricataAnnonaceaeEugenolTraditional medicineEssential oilAnnonaChemistryHumuleneBotanyHorticulture
Citations
25
FWCI
1.10
field-weighted impact
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19
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79%
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