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Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 7- and 5-, 6-, 8-positions

Bioorganic & Medicinal Chemistry Letters · 2005 · Vol. 15(21) · pp. 4745–4751
William KemnitzerShailaja KasibhatlaSongchun JiangHong ZhangJianghong ZhaoShaojuan JiaLifen XuCandace Crogan‐GrundyRéal DenisNancy BarriaultLouis VaillancourtSylvie CharronJennifer A. DoddGiorgio AttardoDenis LabrecqueSerge LamotheHenriette GourdeauBen TsengJohn DreweSui Xiong Cai
Synthesis of Organic CompoundsSynthesis and Biological ActivityMulticomponent Synthesis of HeterocyclesChemistryArylStereochemistryApoptosisLead compoundStructure–activity relationshipCaspase 3Function (biology)Cell growthSubstitution (logic)
Citations
270
FWCI
3.90
field-weighted impact
References
18
Percentile
94%
vs. same field & year
Citations per year
References
Mitochondria and Apoptosis
Science · 1998 · 8,971 citations
Caspase structure, proteolytic substrates, and function during apoptotic cell death
Cell Death and Differentiation · 1999 · 1,540 citations
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