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Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

Gut · 2015 · Vol. 66(1) · pp. 70–78

Jun Yu(BGI Group (China))Qiang Feng(BGI Group (China))Sunny H. Wong(BGI Group (China))Dongya Zhang(BGI Group (China))Qiaoyi Liang(BGI Group (China))Youwen Qin(BGI Group (China))Longqing Tang(BGI Group (China))Hui Zhao(BGI Group (China))Jan Stenvang(University of Copenhagen)Yanli Li(BGI Group (China))Xiaokai Wang(BGI Group (China))Xiaoqiang Xu(BGI Group (China))Ning Chen(BGI Group (China))William Ka Kei Wu(Chinese University of Hong Kong)Jumana Y. Al‐Aama(BGI Group (China))Hans Jørgen Nielsen(Hvidovre Hospital)Pia Kiilerich(University of Copenhagen)Benjamin A. H. Jensen(University of Copenhagen)Tung On Yau(Chinese University of Hong Kong)Zhou Lan(BGI Group (China))Huijue Jia(BGI Group (China))Junhua Li(BGI Group (China))Liang Xiao(BGI Group (China))Thomas Y. Lam(Chinese University of Hong Kong)Siew C. Ng(Chinese University of Hong Kong)Alfred S.L. Cheng(Chinese University of Hong Kong)Vincent Wai‐Sun Wong(Chinese University of Hong Kong)Francis K.L. Chan(Chinese University of Hong Kong)Xun Xu(BGI Group (China))Huanming Yang(BGI Group (China))Lise Madsen(BGI Group (China))Christian Datz(University of Salzburg)Herbert Tilg(Innsbruck Medical University)Jian Wang(BGI Group (China))Jian Wang✉(BGI Group (China))Nils Brünner(BGI Group (China))Karsten Kristiansen(BGI Group (China))Manimozhiyan Arumugam(BGI Group (China))Joseph J.�Y. Sung(BGI Group (China))Jun Wang✉(BGI Group (China))Jun Wang(BGI Group (China))

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Abstract

We present the first metagenomic profiling study of CRC faecal microbiomes to discover and validate microbial biomarkers in ethnically different cohorts, and to independently validate selected biomarkers using an affordable clinically relevant technology. Our study thus takes a step further towards affordable non-invasive early diagnostic biomarkers for CRC from faecal samples.

Gut microbiota and health Colorectal Cancer Screening and Detection Helicobacter pylori-related gastroenterology studiesMetagenomicsMicrobiomeColorectal cancerMedicineCancerGut microbiomeComputational biologyBiologyOncologyBioinformatics