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A meta-analysis of the effect of lowering serum levels of GH and IGF-I on mortality in acromegaly
European Journal of Endocrinology · 2008 · Vol. 159(2) · pp. 89–95
I.M. Holdaway✉(Greenlane Clinical Centre)Mark J Bolland(University of Auckland)G. Gamble(University of Auckland)
Abstract
Clinicians treating acromegalic patients should aim for random serum GH <2.5 microg/l measured by RIA (probably <1 microg/l measured by modern sensitive immunoassay) and normal serum IGF-I values, to restore the elevated mortality of the condition to normal levels.
Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsOphthalmology and Eye DisordersAcromegalyMedicineInternal medicineConfidence intervalMeta-analysisStandardized mortality ratioEndocrinologySomatostatinEndocrine systemGastroenterology
MeSH terms
AcromegalyCause of DeathFollow-Up StudiesHumansInsulin-Like Growth Factor IRemission InductionGrowth HormoneDown-Regulation
Citations
458
FWCI
11.59
field-weighted impact
References
28
Percentile
99%
vs. same field & year
Citations per year
Cited by
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The Journal of Clinical Endocrinology & Metabolism · 2012 · 1,439 citations
Acromegaly: An Endocrine Society Clinical Practice Guideline
The Journal of Clinical Endocrinology & Metabolism · 2014 · 1,747 citations
References
Long‐term outcome and mortality after transsphenoidal adenomectomy for acromegaly
Clinical Endocrinology · 2003 · 299 citations
Determinants of clinical outcome and survival in acromegaly
Clinical Endocrinology · 1994 · 564 citations
EPIDEMIOLOGY OF ACROMEGALY IN THE NEWCASTLE REGION
Clinical Endocrinology · 1980 · 467 citations
Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management
Endocrine Reviews · 2004 · 1,300 citations
Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA)
European Journal of Endocrinology · 2004 · 381 citations
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