articleTop 10% cited

Studies of insulin resistance in patients with clinical and subclinical hypothyroidism

European Journal of Endocrinology · 2009 · Vol. 160(5) · pp. 785–790

Eirini Maratou✉(Hellenic Center for Disease Control & Prevention)D. Hadjidakis(University General Hospital Attikon)Αναστάσιος Κόλλιας(University General Hospital Attikon)Katerina Tsegka(University General Hospital Attikon)Μelpomeni Peppa(University General Hospital Attikon)Maria AlevizakiPanagiota Mitrou(Hellenic Center for Disease Control & Prevention)Vaia Lambadiari(University General Hospital Attikon)Eleni Boutati(University General Hospital Attikon)Daniel Nikzas(Agia Olga Hospital)Nikolaos Tountas(University General Hospital Attikon)Theofanis Economopoulos(University General Hospital Attikon)S. Raptis(University General Hospital Attikon)George Dimitriadis(University General Hospital Attikon)

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Abstract

In patients with HO and SHO: i) insulin resistance was comparable; ii) insulin-stimulated rates of glucose transport in isolated monocytes were decreased due to impaired translocation of GLUT4 glucose transporters on the plasma membrane; iii) these findings could justify the increased risk for insulin resistance-associated disorders, such as cardiovascular disease, observed in patients with HO or SHO.

Thyroid Disorders and Treatments Metabolism, Diabetes, and Cancer Ion Transport and Channel RegulationInternal medicineInsulin resistanceEndocrinologyInsulinEuthyroidMedicineInsulin tolerance testSubclinical infectionHomeostasisCarbohydrate metabolism

MeSH terms

AdultBlood GlucoseCell MembraneCells, CulturedFastingGlucose Tolerance TestHumansHypothyroidismInsulinInsulin ResistanceMiddle AgedMonocytesThyroid Function TestsGlucose Transporter Type 3Glucose Transporter Type 4

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References

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer