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Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR

Nature Structural & Molecular Biology · 2004 · Vol. 11(7) · pp. 591–598
Yuan GuoH. FeinbergE. ConroyDaniel A. MitchellRichard AlvarezOla BlixtMaureen E. TaylorWilliam I. WeisKurt Drickamer
Immunotherapy and Immune ResponsesImmune Cell Function and InteractionT-cell and B-cell ImmunologyDC-SIGNEndocytosisReceptorCell biologyEndosomeLigand (biochemistry)Mannose receptorBiologyPlasma protein bindingChemistry

MeSH terms

DC-Specific ICAM-3 Grabbing NonintegrinBinding SitesHumansHydrogen-Ion ConcentrationLigandsProtein BindingProtein ConformationReceptors, Cell SurfaceCell Adhesion MoleculesMutagenesisCrystallography, X-RayLectins, C-Type

Funding

  • Mizutani Foundation for Glycoscience
  • Wellcome Trust
  • National Institutes of Health
  • Lawrence Berkeley National Laboratory
Citations
602
FWCI
11.45
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33
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99%
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References
Antibodies, a laboratory manual
Biomedicine & Pharmacotherapy · 1989 · 12,466 citations
The C‐type lectin superfamily in the immune system
Immunological Reviews · 1998 · 1,045 citations
Antibodies: A laboratory manual
Trends in Biochemical Sciences · 1989 · 5,154 citations
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