article Open AccessTop 1% cited
The complex transcriptional landscape of the anucleate human platelet
BMC Genomics · 2013 · Vol. 14(1) · pp. 1–1
Paul F. Bray✉(Thomas Jefferson University)Steven E. McKenzie(Thomas Jefferson University)Leonard C. Edelstein(Thomas Jefferson University)Srikanth Nagalla(Thomas Jefferson University)Kathleen Delgrosso(Sidney Kimmel Cancer Center)Adam Ertel(Sidney Kimmel Cancer Center)Joan Kupper(Thomas Jefferson University)Jing Yi(Thomas Jefferson University)Eric Londin(Thomas Jefferson University)Phillipe Loher(Thomas Jefferson University)Huang-Wen Chen(Thomas Jefferson University)Paolo Fortina(Thomas Jefferson University)Isidore Rigoutsos(Thomas Jefferson University)
Abstract
Our analyses revealed diverse classes of non-coding RNAs, including: pervasive antisense transcripts to protein-coding loci; numerous, previously unreported and abundant microRNAs; retrotransposons; and thousands of novel un-annotated long and short intronic transcripts, an intriguing finding considering the anucleate nature of platelets. The data are available through a local mirror of the UCSC genome browser and can be accessed at: http://cm.jefferson.edu/platelets_2012/.
Cancer-related molecular mechanisms researchMicroRNA in disease regulationPlatelet Disorders and TreatmentsBiologyRNATranscriptomeNon-coding RNAGenomeDNA microarraymicroRNALong non-coding RNAGeneticsMessenger RNA
MeSH terms
Blood PlateletsCell NucleusHumansIntronsPseudogenesRNA, MessengerRNA, RibosomalTranscription, GeneticRNA, AntisenseSequence Analysis, RNAReverse Transcriptase Polymerase Chain ReactionInternetGenomicsData Mining
Funding
- W. M. Keck Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
Citations
807
FWCI
15.14
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79
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99%
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References
GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
BMC Bioinformatics · 2009 · 3,658 citations
Non-coding RNAs in human disease
Nature Reviews Genetics · 2011 · 4,860 citations
Fast and accurate short read alignment with Burrows–Wheeler transform
Bioinformatics · 2009 · 61,752 citations
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