article Open AccessTop 10% cited
Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche
British Journal of Ophthalmology · 2005 · Vol. 89(5) · pp. 529–532
Harminder S. Dua✉(Nottingham University Hospitals NHS Trust)
Abstract
A novel anatomical structure has been identified at the human limbus, which demonstrates characteristics of being a stem cell niche. The authors have termed this structure the limbal epithelial crypt.
Corneal Surgery and TreatmentsOcular Surface and Contact LensCorneal surgery and disordersLimbal stem cellStem cellHaematoxylinPathologyCytokeratinBiologyAnatomyCorneaStem cell nicheStem cell marker
MeSH terms
ATP Binding Cassette Transporter, Subfamily G, Member 2HumansKeratinsNeoplasm ProteinsStem CellsLimbus CorneaeATP-Binding Cassette TransportersEpithelium, CornealKeratin-14
Funding
- Royal College of Surgeons of Edinburgh
- Henry Smith Charity
Citations
391
FWCI
9.84
field-weighted impact
References
31
Percentile
98%
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Citations per year
References
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Nature Medicine · 2001 · 2,273 citations
Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells.
The Journal of Cell Biology · 1986 · 1,392 citations
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
The Journal of Experimental Medicine · 1996 · 2,896 citations
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