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Outcomes for COPD pharmacological trials: from lung function to biomarkers

European Respiratory Journal · 2008 · Vol. 31(2) · pp. 416–469

Mario Cazzola✉(University of Rome Tor Vergata)William MacNee(University of Rome Tor Vergata)Fernando J. Martínez(University of Rome Tor Vergata)Klaus F. Rabe(University of Rome Tor Vergata)Luigi G. Franciosi(University of Rome Tor Vergata)Peter J. Barnes(University of Rome Tor Vergata)Vito Brusasco(University of Rome Tor Vergata)P. S. Burge(University of Rome Tor Vergata)Peter Calverley(University of Rome Tor Vergata)Bartolomé R. Celli(University of Rome Tor Vergata)Paul Jones(University of Rome Tor Vergata)Donald A. Mahler(University of Rome Tor Vergata)Barry J. Make(University of Rome Tor Vergata)Marc Miravitlles(University of Rome Tor Vergata)Clive Page(University of Rome Tor Vergata)Paolo Palange(University of Rome Tor Vergata)David Parr(University of Rome Tor Vergata)M. Pistolesi(University of Rome Tor Vergata)Stephen I. Rennard(University of Rome Tor Vergata)Maureen Rutten‐van Mölken(University of Rome Tor Vergata)Robert A. Stockley(University of Rome Tor Vergata)SD SullivanJadwiga A. Wedzicha(University of Rome Tor Vergata)Emiel F.�M. Wouters

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Abstract

The American Thoracic Society/European Respiratory Society jointly created a Task Force on "Outcomes for COPD pharmacological trials: from lung function to biomarkers" to inform the chronic obstructive pulmonary disease research community about the possible use and limitations of current outcomes and markers when evaluating the impact of a pharmacological therapy. Based on their review of the published literature, the following document has been prepared with individual sections that address specific outcomes and markers, and a final section that summarises their recommendations.

Chronic Obstructive Pulmonary Disease (COPD) Research Asthma and respiratory diseases Respiratory Support and MechanismsMedicineCOPDTask forceLung functionIntensive care medicineClinical trialPulmonary diseasePulmonary function testingLungPhysical therapy

MeSH terms

Adrenal Cortex HormonesBronchodilator AgentsClinical Trials as TopicFemaleHumansMalePrognosisRespiratory Function TestsSocieties, MedicalBiomarkersSurvival AnalysisTreatment OutcomePractice Guidelines as TopicRisk AssessmentAdvisory Committees