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Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
Gut · 2006 · Vol. 56(1) · pp. 61–72
Sebastian Zeißig(Charité - Universitätsmedizin Berlin)Natalie Bürgel(Charité - Universitätsmedizin Berlin)Dorothee Günzel(Charité - Universitätsmedizin Berlin)J Richter(Charité - Universitätsmedizin Berlin)Joachim Mankertz(Charité - Universitätsmedizin Berlin)Ulrich Wahnschaffe(Charité - Universitätsmedizin Berlin)A. J. Kroesen(Charité - Universitätsmedizin Berlin)Martin Zeitz(Charité - Universitätsmedizin Berlin)Michael Fromm(Charité - Universitätsmedizin Berlin)JD Schulzke✉(Charité - Universitätsmedizin Berlin)
Abstract
Upregulation of pore-forming claudin 2 and downregulation and redistribution of sealing claudins 5 and 8 lead to altered tight junction structure and pronounced barrier dysfunction already in mild to moderately active Crohn's disease.
Barrier Structure and Function StudiesGut microbiota and healthMycobacterium research and diagnosisTight junctionClaudinOccludinBarrier functionDownregulation and upregulationCell junctionPathologyIntestinal mucosaBiologyChemistry
MeSH terms
AdultAgedCells, CulturedColitis, UlcerativeCrohn DiseaseEpitheliumHumansIntestinal MucosaMaleMembrane ProteinsMicroscopy, Electron, ScanningMiddle AgedColon, SigmoidDown-RegulationUp-Regulation
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References
Multifunctional strands in tight junctions
Nature Reviews Molecular Cell Biology · 2001 · 2,465 citations
Claudins create charge-selective channels in the paracellular pathway between epithelial cells
American Journal of Physiology-Cell Physiology · 2002 · 541 citations
Occludin: a novel integral membrane protein localizing at tight junctions.
The Journal of Cell Biology · 1993 · 2,521 citations
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