articleTop 1% cited
Role of Genes and Environments for Explaining Alzheimer Disease
Archives of General Psychiatry · 2006 · Vol. 63(2) · pp. 168–168
Margaret Gatz✉(University of Southern California)Chandra A. ReynoldsLaura FratiglioniBoo JohanssonJames A. MortimerStig BergAmy FiskeNancy L. Pedersen
Abstract
In the largest twin study to date, we confirmed that heritability for AD is high and that the same genetic factors are influential for both men and women. However, nongenetic risk factors also play an important role and might be the focus for interventions to reduce disease risk or delay disease onset.
Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsGenetic Associations and EpidemiologyHeritabilityTwin studyMonozygotic twinDiseaseDizygotic twinsDizygotic twinDementiaDemographyPsychologyPopulation
MeSH terms
AgedAged, 80 and overAlzheimer DiseaseDiseases in TwinsFemaleHumansMaleModels, GeneticPhenotypeRegistriesRisk FactorsSex FactorsSocial EnvironmentSwedenTwins, Dizygotic
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