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Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

New England Journal of Medicine · 2011 · Vol. 364(23) · pp. 2187–2198

Craig R. Smith✉(Columbia University Irving Medical Center)Martin B. Leon(NewYork–Presbyterian Hospital)Michael J. Mack(Baylor Scott & White Health)D. Craig Miller(Palo Alto University)Jeffrey W. Moses(New York Hospital Queens)Lars G. Svensson(Cleveland Clinic)E. Murat Tuzcu(Cleveland Clinic)John G. Webb(St. Paul's Hospital)Gregory P. Fontana(Cedars-Sinai Medical Center)Raj Makkar(Cedars-Sinai Medical Center)Mathew Williams(New York Hospital Queens)Todd Dewey(Medical City Dallas Hospital)Samir Kapadia(Cleveland Clinic)Vasilis Babaliaros(Emory University)Vinod H. Thourani(Emory University)Paul J. Corso(MedStar Washington Hospital Center)Augusto D. Pichard(MedStar Washington Hospital Center)Joseph E. Bavaria(Hospital of the University of Pennsylvania)Howard C. Herrmann(Hospital of the University of Pennsylvania)Jodi J. Akin(Edwards Lifesciences (United States))William N. Anderson(Edwards Lifesciences (United States))Duolao Wang(London School of Hygiene & Tropical Medicine)Stuart Pocock(London School of Hygiene & Tropical Medicine)

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Abstract

In high-risk patients with severe aortic stenosis, transcatheter and surgical procedures for aortic-valve replacement were associated with similar rates of survival at 1 year, although there were important differences in periprocedural risks. (Funded by Edwards Lifesciences; Clinical Trials.gov number, NCT00530894.).

Cardiac Valve Diseases and Treatments Infective Endocarditis Diagnosis and Management Aortic Disease and Treatment ApproachesMedicineValve replacementStenosisAortic valve replacementSurgeryConfidence intervalAortic valve stenosisClinical endpointStroke (engine)Randomized controlled trial

MeSH terms

AgedAged, 80 and overAortic ValveAortic Valve StenosisCardiovascular DiseasesCatheterizationFemaleCardiac CatheterizationHumansMalePostoperative ComplicationsRisk FactorsHeart Valve Prosthesis ImplantationStrokeIntention to Treat Analysis

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