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Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery

New England Journal of Medicine · 2010 · Vol. 363(17) · pp. 1597–1607

Martin B. Leon✉(NewYork–Presbyterian Hospital)Craig R. Smith(New York Hospital Queens)Michael J. Mack(Medical City Dallas Hospital)D. Craig Miller(Stanford University)Jeffrey W. Moses(New York Hospital Queens)Lars G. Svensson(Cleveland Clinic)E. Murat Tuzcu(Cleveland Clinic)John G. Webb(St. Paul's Hospital)Gregory P. Fontana(Cedars-Sinai Medical Center)Raj Makkar(Cedars-Sinai Medical Center)David L. Brown(Medical City Dallas Hospital)Peter C. Block(Emory University)Robert A. Guyton(Emory University)Augusto D. Pichard(MedStar Washington Hospital Center)Joseph E. Bavaria(Hospital of the University of Pennsylvania)Howard C. Herrmann(Hospital of the University of Pennsylvania)Pamela S. Douglas(Duke Medical Center)John L. Petersen(Duke Medical Center)Jodi J. Akin(Edwards Lifesciences (United States))William N. Anderson(Edwards Lifesciences (United States))Duolao Wang(London School of Hygiene & Tropical Medicine)Stuart Pocock(London School of Hygiene & Tropical Medicine)

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Abstract

In patients with severe aortic stenosis who were not suitable candidates for surgery, TAVI, as compared with standard therapy, significantly reduced the rates of death from any cause, the composite end point of death from any cause or repeat hospitalization, and cardiac symptoms, despite the higher incidence of major strokes and major vascular events. (Funded by Edwards Lifesciences; ClinicalTrials.gov number, NCT00530894.).

Cardiac Valve Diseases and Treatments Cardiovascular Function and Risk Factors Infective Endocarditis Diagnosis and ManagementMedicineStenosisAortic valve replacementCardiologyInternal medicineAortic valve stenosisAortic valveSurgery

MeSH terms

AgedAged, 80 and overAortic Valve StenosisCardiovascular DiseasesCatheterizationEchocardiographyFemaleCardiac CatheterizationHospitalizationHumansMaleProspective StudiesTreatment OutcomeHeart Valve Prosthesis ImplantationKaplan-Meier Estimate

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