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Cisplatin: mode of cytotoxic action and molecular basis of resistance

Oncogene · 2003 · Vol. 22(47) · pp. 7265–7279
Zahid H. Siddik
Cancer therapeutics and mechanismsDNA Repair MechanismsMetal complexes synthesis and propertiesCisplatinDNA damageBiologyApoptosisSignal transductionDNA repairProtein kinase BCancer researchCell biologyMode of action

MeSH terms

CisplatinDNA DamageDNA RepairHumansTumor Suppressor Protein p53ApoptosisDrug Resistance, NeoplasmMAP Kinase Signaling System

Funding

  • National Institutes of Health
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References
Post‐translational modifications and activation of p53 by genotoxic stresses
European Journal of Biochemistry · 2001 · 1,073 citations
Regulation of p53 in response to DNA damage
Oncogene · 1999 · 995 citations
The Hallmarks of Cancer
Cell · 2000 · 28,385 citations
p53 Mutations in Human Cancers
Science · 1991 · 8,098 citations
Mitogen-activated protein kinase pathways
Current Opinion in Cell Biology · 1997 · 2,492 citations
A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins
JNCI Journal of the National Cancer Institute · 2000 · 1,754 citations
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