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T-lymphocyte Infiltration in Visceral Adipose Tissue

Arteriosclerosis Thrombosis and Vascular Biology · 2008 · Vol. 28(7) · pp. 1304–1310

Ulrich Kintscher✉(Leipzig University)Martin Hartge(Leipzig University)Katharina Heß(Universität Ulm)Anna Foryst‐Ludwig(Universität Ulm)Markus Clemenz(Leipzig University)Martin Wabitsch(Universität Ulm)Pamela Fischer‐Posovszky(Universität Ulm)Thomas F.E. Barth(Universität Ulm)Duska Dragun(Universität Ulm)Thomas Skurk(Leipzig University)Hans Hauner(Universität Ulm)Matthias Blüher(Universität Ulm)Thomas Unger(Universität Ulm)Anna-Maria Wolf(Universität Ulm)Uwe Knippschild(Leipzig University)Vinzenz Hombach(Leipzig University)Nikolaus Marx(Universität Ulm)

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Abstract

Proinflammatory T-lymphocytes are present in visceral adipose tissue and may contribute to local inflammatory cell activation before the appearance of macrophages, suggesting that these cells could play an important role in the initiation and perpetuation of adipose tissue inflammation as well as the development of IR.

Adipokines, Inflammation, and Metabolic Diseases Immune Cell Function and Interaction Adipose Tissue and MetabolismAdipose tissueAdipose tissue macrophagesInflammationInfiltration (HVAC)Proinflammatory cytokineMacrophageLymphocyteEndocrinologyInternal medicineWhite adipose tissue

MeSH terms

AgedAnimalsCell MovementCells, CulturedDiabetes Mellitus, Type 2Dietary FatsDisease Models, AnimalHumansInsulin ResistanceInterferon-gammaMacrophagesMaleMice, Inbred C57BLMiddle AgedObesity

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675

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30.49

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Adipose tissue inflammation and metabolic dysfunction in obesity