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Detection of Huntington's disease decades before diagnosis: the Predict-HD study

Journal of Neurology Neurosurgery & Psychiatry · 2007 · Vol. 79(8) · pp. 874–880

Jane S. Paulsen✉(University of Iowa)Douglas R. Langbehn(University of Iowa)Julie C. Stout(Indiana University Bloomington)Elizabeth Aylward(University of Washington)C A Ross(Johns Hopkins University)Martha Nance(Park Nicollet Clinic)Mark Guttman(Centre for Movement Disorders)S Johnson(Indiana University Bloomington)Marcy E. MacDonald(Massachusetts General Hospital)Leigh J. Beglinger(University of Iowa)Karen Duff(University of Iowa)Elise Kayson(University of Rochester)Kevin Biglan(University of Rochester)Ira Shoulson(University of Rochester)David Oakes(University of Rochester Medical Center)Michael R. Hayden(University of British Columbia)The Predict-HD Investigators and Coordinators of the Huntington Study Group

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Abstract

These findings from the Predict-HD study suggest the approximate time scale of measurable disease development, and suggest candidate disease markers for use in preventive HD trials.

Genetic Neurodegenerative Diseases Mitochondrial Function and PathologyHuntington's diseaseDiseaseNeuroimagingMedicinePsychologyInternal medicinePsychiatry

MeSH terms

Huntingtin ProteinAdultAgedOlfaction DisordersAttentionCaudate NucleusChromosomes, Human, Pair 4FemaleGenetic TestingHumansHuntington DiseaseLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle Aged