articleTop 1% cited
Size Effect on Cell Uptake in Well‐Suspended, Uniform Mesoporous Silica Nanoparticles
Small · 2009 · Vol. 5(12) · pp. 1408–1413
Fang Lu(National Taiwan University)Si‐Han Wu(National Taiwan University)Yann Hung(National Taiwan University)Chung‐Yuan Mou✉(National Taiwan University)
Abstract
The size of it: Mesoporous silica nanoparticles (MSNs) of controlled size in the range 30 to 280 nm are obtained by adjusting the pH of the reaction solution. The uptake of fluorescein-labeled MSNs (green, see image) by HeLa cells is size-dependent, with maximum uptake at a nanoparticle size of 50 nm.
Mesoporous Materials and CatalysisNanoparticle-Based Drug DeliveryAdvanced biosensing and bioanalysis techniquesMesoporous silicaNanoparticleMesoporous materialMaterials scienceHeLaParticle sizeChemical engineeringNanotechnologyCell sizeFluorescein
MeSH terms
HeLa CellsHumansHydrogen-Ion ConcentrationLightParticle SizeScattering, RadiationSilicon DioxideX-Ray DiffractionPorosityFluorescein-5-isothiocyanateMicroscopy, ConfocalMicroscopy, Electron, TransmissionNanoparticles
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