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Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs

Small · 2007 · Vol. 3(8) · pp. 1341–1346

Jie Lü✉(University of California, Los Angeles)Monty Liong(California NanoSystems Institute)Jeffrey I. Zink(University of California, Los Angeles)Fuyuhiko Tamanoi(California NanoSystems Institute)

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Abstract

Special delivery: The hydrophobic anticancer drug camptothecin was incorporated into fluorescent mesoporous silica nanoparticles (see image) and delivered to various cancer cells to induce cell death. These results suggest a method to overcome the insolubility problem of many anticancer drugs, which is considered to be one of the major challenges in cancer therapy.

Nanoparticle-Based Drug Delivery Mesoporous Materials and Catalysis Nanoplatforms for cancer theranosticsMesoporous silicaCamptothecinDrug deliveryNanoparticleNanotechnologyAnticancer drugCancer therapyCancer cellCancerMaterials science

MeSH terms

Antineoplastic AgentsCamptothecinCrystallizationDiffusionDrug CarriersHumansMaterials TestingMolecular ConformationNeoplasmsParticle SizeSilicon DioxideSurface PropertiesPorosityApoptosisNanotechnology

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Synthesis of spherical mesoporous silica nanoparticles with nanometer-size controllable pores and outer diameters