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Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

JNCI Journal of the National Cancer Institute · 2000 · Vol. 92(7) · pp. 564–569

Manel Esteller✉(Meertens Institute)

Abstract

Silencing of the BRCA1 gene by promoter hypermethylation occurs in primary breast and ovarian carcinomas, especially in the presence of LOH and in specific histopathologic subgroups. These findings support a role for this tumor suppressor gene in sporadic breast and ovarian tumorigenesis.

BRCA gene mutations in cancer Epigenetics and DNA Methylation Genomic variations and chromosomal abnormalitiesLoss of heterozygosityMethylationCancer researchDNA methylationBiologyTumor suppressor geneOvarian cancerBreast cancerGeneMolecular biology

MeSH terms

Breast NeoplasmsFemaleHumansMethylationOvarian NeoplasmsPromoter Regions, GeneticRNARNA, NeoplasmTransplantation, HeterologousTumor Cells, CulturedGene Expression Regulation, NeoplasticCarcinoma, Ductal, BreastGenes, BRCA1Loss of HeterozygosityReverse Transcriptase Polymerase Chain Reaction

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CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at <i>BRCA1</i> promoter