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Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength
The Journals of Gerontology Series A · 2009 · Vol. 64A(11) · pp. 1183–1189
L. Schaap✉(EMGO Institute for Health and Care Research)Saskia M.F. Pluijm(Erasmus University Rotterdam)D.J.H. Deeg(EMGO Institute for Health and Care Research)T. B. Harris(National Institute on Aging)Stephen B. Kritchevsky(Wake Forest University)Anne B. Newman(University of Pittsburgh)Lisa H. Colbert(University of Wisconsin–Madison)M. Pahor(Institute on Aging)S. M. Rubin(University of California, San Francisco)Frances A. Tylavsky(University of Tennessee Health Science Center)Marjolein Visser(EMGO Institute for Health and Care Research)for the Health ABC Study
Abstract
TNF-alpha and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.
Nutrition and Health in AgingAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesSarcopeniaGrip strengthAgeingInternal medicineInflammationMedicineReceptorEndocrinologyTumor necrosis factor alphaInterleukin 6
MeSH terms
AgedC-Reactive ProteinFemaleHumansMaleTumor Necrosis Factor-alphaInterleukin-6Linear ModelsMuscle, SkeletalHand StrengthReceptors, Interleukin-6Receptors, Tumor Necrosis Factor, Type IMuscle Strength
Funding
- National Institutes of Health
Citations
671
FWCI
11.81
field-weighted impact
References
35
Percentile
99%
vs. same field & year
Citations per year
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References
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2000 · 433 citations
Serum IL‐6 Level and the Development of Disability in Older Persons
Journal of the American Geriatrics Society · 1999 · 805 citations
Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly
The American Journal of Medicine · 1999 · 1,479 citations
Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study
The Journals of Gerontology Series A · 2004 · 890 citations
Relationship of Interleukin-6 and Tumor Necrosis Factor- With Muscle Mass and Muscle Strength in Elderly Men and Women: The Health ABC Study
The Journals of Gerontology Series A · 2002 · 1,254 citations
Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study
Journal of Applied Physiology · 2001 · 1,206 citations
Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength
The American Journal of Medicine · 2006 · 1,018 citations
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