articleTop 1% cited
Serum IL‐6 Level and the Development of Disability in Older Persons
Journal of the American Geriatrics Society · 1999 · Vol. 47(6) · pp. 639–646
Luigi Ferrucci✉(Istituto Nazionale di Riposo e Cura per Anziani)Tamara B. HarrisJack M. GuralnikRussell P. Tracy(University of Vermont)Maria‐Chiara Corti(University of Padua)Harvey Jay Cohen(Duke University)B. PenninxMarco Pahor(University of Tennessee at Knoxville)Robert B. Wallace(University of Iowa)Richard J. Havlik
Abstract
Higher circulating levels of IL-6 predict disability onset in older persons. This may be attributable to a direct effect of IL-6 on muscle atrophy and/or to the pathophysiologic role played by IL-6 in specific diseases.
Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic DiseasesFibromyalgia and Chronic Fatigue Syndrome ResearchMedicineConfoundingActivities of daily livingGerontologyPhysical therapyInternal medicine
MeSH terms
Activities of Daily LivingAgedAgingEnzyme-Linked Immunosorbent AssayFemaleDisabled PersonsPersons with DisabilitiesHumansIowaLongitudinal StudiesMalePrognosisRandom AllocationInterleukin-6Confounding Factors, Epidemiologic
Funding
- National Institute on Aging
Citations
805
FWCI
18.77
field-weighted impact
References
46
Percentile
100%
vs. same field & year
Citations per year
Cited by
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Annals of the New York Academy of Sciences · 2000 · 5,113 citations
Relationship of Interleukin-6 and Tumor Necrosis Factor- With Muscle Mass and Muscle Strength in Elderly Men and Women: The Health ABC Study
The Journals of Gerontology Series A · 2002 · 1,254 citations
Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength
The Journals of Gerontology Series A · 2009 · 671 citations
Immune activation and inflammation in HIV‐1 infection: causes and consequences
The Journal of Pathology · 2007 · 736 citations
Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength
The American Journal of Medicine · 2006 · 1,018 citations
Prognostic Value of Usual Gait Speed in Well‐Functioning Older People—Results from the Health, Aging and Body Composition Study
Journal of the American Geriatrics Society · 2005 · 1,193 citations
Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway
The Journals of Gerontology Series A · 2006 · 704 citations
Endocrine and inflammatory markers as predictors of frailty
Clinical Endocrinology · 2005 · 318 citations
References
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Journal of Clinical Investigation · 1995 · 3,504 citations
A Short Portable Mental Status Questionnaire for the Assessment of Organic Brain Deficit in Elderly Patients†
Journal of the American Geriatrics Society · 1975 · 5,320 citations
What Is Sarcopenia?
The Journals of Gerontology Series A · 1995 · 602 citations
Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
Journal of Bone and Mineral Research · 1996 · 740 citations
The Yin and Yang of Oxidation in the Development of the Fatty Streak
Arteriosclerosis Thrombosis and Vascular Biology · 1996 · 693 citations
Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly
Arteriosclerosis Thrombosis and Vascular Biology · 1997 · 837 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.