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Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Archives of Neurology · 2005 · Vol. 62(10) · pp. 1556–60
Miia Kivipelto✉(Karolinska Institutet)Tiia NganduLaura FratiglioniMatti ViitanenIngemar KåreholtBengt WinbladEeva‐Liisa HelkalaJaakko TuomilehtoHilkka SoininenAulikki Nissinen
Abstract
Obesity at midlife is associated with an increased risk of dementia and AD later in life. Clustering of vascular risk factors increases the risk in an additive manner. The role of weight reduction for the prevention of dementia needs to be further investigated.
Nutritional Studies and DietDiet and metabolism studiesNutrition and Health in AgingDementiaBody mass indexMedicineOdds ratioRisk factorInternal medicineObesityVascular dementiaPopulationBlood pressure
MeSH terms
Age FactorsAgedAlzheimer DiseaseCholesterolDementiaFemaleHumansHypertensionMaleMiddle AgedObesityRisk FactorsBody Mass Index
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References
Midlife blood pressure and dementia: the Honolulu–Asia aging study☆
Neurobiology of Aging · 2000 · 993 citations
Association of diabetes mellitus and dementia: The Rotterdam Study
Diabetologia · 1996 · 674 citations
The Clinical Diagnosis of Alzheimer's Disease
Archives of Neurology · 1987 · 1,380 citations
Actual Causes of Death in the United States, 2000
JAMA · 2004 · 5,241 citations
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>
JAMA · 2003 · 25,504 citations
Clinical diagnosis of Alzheimer's disease
Neurology · 1984 · 27,910 citations
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
New England Journal of Medicine · 2001 · 10,897 citations
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