review Open AccessTop 1% cited
The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences
Clinical Chemistry · 2008 · Vol. 54(6) · pp. 945–955
Sarah D. de Ferranti✉(Boston Children's Museum)Dariush Mozaffarian(Harvard University)
Abstract
Adipocyte endoplasmic reticulum and mitochondrial stress, and associated changes in circulating adipokines, free fatty acids, and inflammatory mediators, are central to adverse health effects of adiposity. Future investigation should focus on these pathways and on reversing the adverse lifestyle behaviors that are the fundamental causes of adiposity.
Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesDiet and metabolism studiesAdipocyteEndocrinologyInternal medicineMedicineFatty liverInsulin resistanceAdipokineAdipose tissueDiabetes mellitusDisease
MeSH terms
AnimalsEndoplasmic ReticulumEnergy MetabolismFatty Acids, NonesterifiedHumansInsulin ResistanceLife StyleMitochondriaObesityAdipocytesOxidative StressInflammation MediatorsPostprandial PeriodCell SizeCell Proliferation
Funding
- National Institutes of Health
- National Heart, Lung, and Blood Institute
Citations
727
FWCI
27.82
field-weighted impact
References
96
Percentile
100%
vs. same field & year
Citations per year
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