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Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

Arteriosclerosis Thrombosis and Vascular Biology · 2014 · Vol. 34(8) · pp. 1731–1738

Siroon Bekkering✉(Radboud University Nijmegen)Jessica Quintin(Radboud University Nijmegen)Leo A. B. Joosten(Radboud University Nijmegen)J.W.M. van der Meer(Radboud University Nijmegen)Mihai G. Netea(Radboud University Nijmegen)Niels P. Riksen(Radboud University Nijmegen)

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Abstract

Brief exposure of monocytes to a low concentration of oxLDL induces a long-lasting proatherogenic macrophage phenotype via epigenetic histone modifications, characterized by increased proinflammatory cytokine production and foam cell formation.

Immune responses and vaccinations Immune cells in cancer Phagocytosis and Immune RegulationProinflammatory cytokineScavenger receptorCD36Foam cellChemistryMonocyteDownregulation and upregulationTumor necrosis factor alphaInflammationCell biology

MeSH terms

ATP Binding Cassette Transporter, Subfamily G, Member 1Histone MethyltransferasesCells, CulturedEnzyme InhibitorsFoam CellsHistonesHumansLipoproteins, LDLMonocytesPhenotypePromoter Regions, GeneticHistone-Lysine N-MethyltransferaseRNA, MessengerTime FactorsCytokines

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684

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Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases