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Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides

Biochimica et Biophysica Acta (BBA) - Biomembranes · 1999 · Vol. 1462(1-2) · pp. 55–70
Yechiel Shai
Antimicrobial Peptides and ActivitiesLipid Membrane Structure and BehaviorImmune Response and InflammationAntimicrobial peptidesMembraneLytic cycleLysisLipid bilayerBiophysicsTransmembrane proteinChemistryCell membranePeptide

MeSH terms

AnimalsAnti-Infective AgentsCell MembraneLipid BilayersMembrane LipidsModels, MolecularPeptidesPermeabilityPhospholipidsProtein BindingProtein Structure, SecondaryAntimicrobial Cationic PeptidesAmphibian ProteinsXenopus Proteins
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References
Experimentally determined hydrophobicity scale for proteins at membrane interfaces
Nature Structural & Molecular Biology · 1996 · 1,655 citations
The Preference of Tryptophan for Membrane Interfaces
Biochemistry · 1998 · 909 citations
Amphipathic helix motif: Classes and properties
Proteins Structure Function and Bioinformatics · 1990 · 640 citations
Peptide Antibiotics and Their Role in Innate Immunity
Annual Review of Immunology · 1995 · 1,614 citations
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