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XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study
Diabetes Care · 2004 · Vol. 27(1) · pp. 155–161
Jarl Torgerson✉(Sahlgrenska University Hospital)Jonathan Hauptman(La Roche College)Mark Boldrin(La Roche College)Lars Sjöström(Sahlgrenska University Hospital)
Abstract
Compared with lifestyle changes alone, orlistat plus lifestyle changes resulted in a greater reduction in the incidence of type 2 diabetes over 4 years and produced greater weight loss in a clinically representative obese population. Difference in diabetes incidence was detectable only in the IGT subgroup; weight loss was similar in subjects with IGT or NGT [correction].
Pharmacology and Obesity TreatmentDiabetes Treatment and ManagementMetabolism, Diabetes, and CancerOrlistatMedicineOverweightPlaceboDiabetes mellitusInternal medicineImpaired glucose toleranceType 2 diabetesWeight lossIncidence (geometry)
MeSH terms
OrlistatAdultEnergy IntakeDiabetes MellitusDouble-Blind MethodFemaleGlucose Tolerance TestHumansLactonesLife StyleLipaseMaleMiddle AgedObesityPlacebos
Citations
1,885
FWCI
98.89
field-weighted impact
References
23
Percentile
100%
vs. same field & year
Citations per year
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JAMA · 1999 · 4,806 citations
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Diabetes Care · 1997 · 4,307 citations
Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin
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