article Open AccessTop 1% cited
Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
Arthritis & Rheumatism · 2005 · Vol. 52(11) · pp. 3381–3390
Y P M Goekoop-Ruiterman✉(Leiden University Medical Center)Jeska K de Vries‐Bouwstra(Amsterdam UMC Location VUmc)Cornelia F Allaart(Leiden University Medical Center)D. van Zeben(Sint Franciscus Gasthuis)P. J. S. M. KerstensJohanna M W Hazes(Erasmus MC)A. H. Zwinderman(Academic Medical Center)H. K. Ronday(Haga Hospital)K. H. Han(GGD Rotterdam-Rijnmond)M L Westedt(Bronovo Hospital)A. Gerards(Franciscus Vlietland)J.H.L.M. van Groenendael(Sint Franciscus Gasthuis)Willem F. Lems(Slotervaartziekenhuis)M V van KrugtenF. C. Breedveld(Leiden University Medical Center)Ben A. C. Dijkmans(Amsterdam UMC Location VUmc)
Abstract
In patients with early RA, initial combination therapy including either prednisone or infliximab resulted in earlier functional improvement and less radiographic damage after 1 year than did sequential monotherapy or step-up combination therapy.
Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders ResearchSystemic Lupus Erythematosus ResearchRheumatoid arthritisMedicineRandomized controlled trialRadiographyInternal medicinePhysical therapySurgery
MeSH terms
InfliximabAntibodies, MonoclonalArthritis, RheumatoidArthrographyDose-Response Relationship, DrugDrug Therapy, CombinationFemaleHealth StatusHumansJointsMaleMiddle AgedPrednisoneRemission InductionRheumatology
Citations
1,457
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54.93
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37
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