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Converting a breast cancer microarray signature into a high-throughput diagnostic test

BMC Genomics · 2006 · Vol. 7(1) · pp. 278–278

Annuska M. Glas✉(Slotervaartziekenhuis)Arno Floore(Slotervaartziekenhuis)Leonie Delahaye(Slotervaartziekenhuis)Anke Witteveen(Slotervaartziekenhuis)Rob Pover(Agendia (Netherlands))Niels Bakx(Slotervaartziekenhuis)Jaana Lahti‐Domenici(Slotervaartziekenhuis)Tako J. Bruinsma(Agendia (Netherlands))Marc O. Warmoes(Slotervaartziekenhuis)René Bernards(Agendia (Netherlands))Lodewyk F.A. Wessels(The Netherlands Cancer Institute)Laura van ‘t Veer(Slotervaartziekenhuis)

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Abstract

In this report we demonstrate for the first time that microarray technology can be used as a reliable diagnostic tool. The data clearly demonstrate the reproducibility and robustness of the small custom-made microarray. The array is therefore an excellent tool to predict outcome of disease in breast cancer patients.

Gene expression and cancer classification Advanced Biosensing Techniques and Applications Bioinformatics and Genomic NetworksMicroarrayDNA microarrayBreast cancerMicroarray analysis techniquesGene chip analysisTissue microarrayBiologyComputational biologyBioinformaticsOncology

MeSH terms

Breast NeoplasmsFemaleHumansMiddle AgedPrognosisSensitivity and SpecificityBiomarkers, TumorReproducibility of ResultsOligonucleotide Array Sequence AnalysisGene Expression ProfilingKaplan-Meier Estimate

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