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Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

Antimicrobial Agents and Chemotherapy · 1991 · Vol. 35(8) · pp. 1647–1650

Hisahiro Yoshida✉(Sumitomo Dainippon Pharma (Japan))M Bogaki(Sumitomo Dainippon Pharma (Japan))Mami Nakamura(Sumitomo Dainippon Pharma (Japan))L M Yamanaka(Sumitomo Dainippon Pharma (Japan))Shinichi Nakamura(Sumitomo Dainippon Pharma (Japan))

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Abstract

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

Cancer therapeutics and mechanisms Antibiotic Resistance in Bacteria DNA and Nucleic Acid ChemistryDNA gyraseQuinoloneMutantEscherichia coliAsparaginePoint mutationBiologyMicrobiologyMutationAspartic acid

MeSH terms

Amino Acid SequenceBinding SitesChemistry, PhysicalDNA Topoisomerases, Type IIDNA, BacterialDrug Resistance, MicrobialEscherichia coliMolecular Sequence DataMutationQuinolonesChemical Phenomena

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Antimicrobial Resistance in ESKAPE Pathogens