review Open AccessTop 1% cited
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Cell · 2003 · Vol. 113(6) · pp. 685–700
Yigong Shi✉(Princeton University)Joan Massagué✉(Memorial Sloan Kettering Cancer Center)
TGF-β signaling in diseasesCancer-related gene regulationKruppel-like factors researchBiologySMADCell biologySignal transductionPhosphorylationNucleusR-SMADSmad2 ProteinCellCell membrane
MeSH terms
AnimalsCell MembraneCell NucleusDNA-Binding ProteinsEukaryotic CellsHumansModels, MolecularSignal TransductionTrans-ActivatorsTransforming Growth Factor betaReceptors, Transforming Growth Factor betaActive Transport, Cell NucleusSmad Proteins
Citations
5,831
FWCI
96.13
field-weighted impact
References
151
Percentile
100%
vs. same field & year
Citations per year
Cited by
Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks
Journal of Clinical Medicine · 2016 · 313 citations
Non-Smad TGF-β signals
Journal of Cell Science · 2005 · 1,071 citations
TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition
Molecular Biology of the Cell · 2005 · 587 citations
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
Annual Review of Immunology · 2005 · 2,164 citations
TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
Development · 2005 · 883 citations
Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications
Endocrine Reviews · 2012 · 1,838 citations
Mechanisms of metastasis: Epithelial‐to‐mesenchymal transition and contribution of tumor microenvironment
Journal of Cellular Biochemistry · 2007 · 367 citations
Role of Smads in TGFβ signaling
Cell and Tissue Research · 2011 · 322 citations
References
Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
Nature Cell Biology · 2003 · 1,158 citations
Regulation of cell proliferation by Smad proteins
Journal of Cellular Physiology · 2002 · 448 citations
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
The EMBO Journal · 2002 · 1,119 citations
Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation
Molecular Cell · 2000 · 1,326 citations
Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators
Developmental Biology · 2002 · 603 citations
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
Journal of Applied Crystallography · 1991 · 14,142 citations
The Protein Kinase Complement of the Human Genome
Science · 2002 · 8,071 citations
TGF-β SIGNAL TRANSDUCTION
Annual Review of Biochemistry · 1998 · 7,560 citations
Related articles
Smad regulation in TGF-β signal transduction
Journal of Cell Science · 2001 · 924 citations
Divergence and convergence of TGF‐β/BMP signaling
Journal of Cellular Physiology · 2001 · 505 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
