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Locus Coeruleus Lesions Suppress the Seizure‐Attenuating Effects of Vagus Nerve Stimulation

Epilepsia · 1998 · Vol. 39(7) · pp. 709–714

Scott E. Krahl✉(West Los Angeles College)Kevin B. Clark(Southern Illinois University Carbondale)Douglas C. Smith(Southern Illinois University Carbondale)Ronald A. Browning(Southern Illinois University Carbondale)

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Abstract

Our data indicate that the LC is involved in the circuitry necessary for the anticonvulsant effects of VNS. Seizure suppression by VNS may therefore depend on the release of NE, a neuromodulator that has anticonvulsant effects. These data suggest that noradrenergic agonists might enhance VNS-induced seizure suppression.

Vagus Nerve Stimulation Research Nicotinic Acetylcholine Receptors Study EEG and Brain-Computer InterfacesLocus coeruleusVagus nerve stimulationAnticonvulsantEpilepsyVagus nerveStimulationMedicineNorepinephrinePharmacologyLidocaine

MeSH terms

AnimalsElectroshockElectric Stimulation TherapyFemaleHydroxydopaminesLidocaineLocus CoeruleusNorepinephrineSeizuresSeverity of Illness IndexVagus NerveRats, Sprague-DawleyRats

Citations

554

FWCI

11.24

field-weighted impact

References

Percentile

99%

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Cited by

Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice