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Risk Factors for Lung Cancer and for Intervention Effects in CARET, the Beta-Carotene and Retinol Efficacy Trial

JNCI Journal of the National Cancer Institute · 1996 · Vol. 88(21) · pp. 1550–1559

Gilbert S. Omenn✉(Cancer Research Center)Gary E. Goodman(Fred Hutch Cancer Center)Mark Thornquist(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa)John R. Balmes(University of California, San Francisco)Mark R. Cullen(Yale University)Andrew Glass(Kaiser Permanente Center for Health Research)James P. Keogh(University of Maryland, Baltimore)Frank L. Meyskens(University of California, Irvine)Barbara Valanis(Kaiser Permanente Center for Health Research)J. H. Williams(University of California, Irvine)Scott Barnhart(Fred Hutch Cancer Center)Martin G. Cherniack(Yale University)Carl A. Brodkin(Fred Hutch Cancer Center)Samuel P. Hammar(University of Washington)

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Abstract

CARET participants receiving the combination of beta-carotene and vitamin A had no chemopreventive benefit and had excess lung cancer incidence and mortality. The results are highly consistent with those found for beta-carotene in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study in 29133 male smokers in Finland.

Antioxidant Activity and Oxidative Stress Retinoids in leukemia and cellular processes Nutritional Studies and DietMedicineRetinolVitaminLung cancerbeta-CaroteneInternal medicinePlaceboCancerGastroenterologyPhysiology

MeSH terms

Retinyl EstersAntioxidantsAsbestosCarcinogensDiterpenesDouble-Blind MethodDrug Therapy, CombinationFemaleHumansLung NeoplasmsMaleRisk FactorsSmokingVitamin AProportional Hazards Models

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