article Open AccessTop 1% cited
Can Animal Models of Disease Reliably Inform Human Studies?
PLoS Medicine · 2010 · Vol. 7(3) · pp. e1000245–e1000245
H. Bart van der Worp✉(University Medical Center Utrecht)David W. Howells(Austin Health)Emily S. Sena(National Stroke Foundation)Michelle J. Porritt(National Stroke Foundation)Sarah Rewell(National Stroke Foundation)Victoria O’Collins(National Stroke Foundation)Malcolm Macleod(University of Edinburgh)
Abstract
H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.
Animal testing and alternativesComputational Drug Discovery MethodsAnesthesia and Neurotoxicity ResearchDiseaseMedicineMEDLINEIntensive care medicineBiologyPathology
MeSH terms
AnimalsDisease Models, AnimalHumansReproducibility of ResultsPublication BiasTranslational Research, Biomedical
Funding
- Medical Research Council
- National Health and Medical Research Council
Citations
1,313
FWCI
69.58
field-weighted impact
References
55
Percentile
100%
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Citations per year
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